This article analyzes the results of using a keyhole approach to treat 30 cases (diameter ≤3 cm) of intracranial minimally invasive lesions (navigation group) under the guidance of Heal Force Excelim-04 neurosurgical system at the First Affiliated Hospital of Guiyang Medical College. At the same time, 25 cases (microsurgery group) with simple microsurgery were used for multiple index control. It was concluded that keyhole surgery is superior to traditional microsurgery in the treatment of intracranial microlesions with the aid of a neuronavigation system.